Glioblastom

Glioblastome gehören zu den häufigsten primären Tumoren im Zentralnervensystem (ZNS). Die Diagnosestellung erfolgt anhand histomorphologischer und molekularer Kriterien, die jüngst durch die Weltgesundheitsorganisation (WHO) neu definiert wurden. Die leitliniengerechte Therapie besteht aus neurochirurgischer Intervention (Biopsie oder Resektion) und anschließend im Wesentlichen aus einer Kombination der Modalitäten Radiotherapie, Chemotherapie (Temozolomid, ggf. kombiniert mit Lomustin) und ggf. Tumortherapiefelder. Klinische Therapiestudien sind integraler Bestandteil einer modernen neuroonkologischen Versorgung. In den aktuellen Phase-I/II-Studien kommen innovative Biomarker-basierte Therapiekonzepte zum Einsatz, teils mit molekular zielgerichteten Substanzen, teils mit personalisierter Immuntherapie.

Schlüsselwörter

Neuroonkologie - Glioblastom - Therapie

• Literatur

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